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KMID : 0356420040220030118
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Journal of Korean Andrology
2004 Volume.22 No. 3 p.118 ~ p.123
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Intracavernosal Injection of Insulin Like Growth Factor-1 Improves Erectile Function in Aging Rat
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Ahn Kyu-Youn
Park Kwang-Sung
Oh Kyung-Jin
Kim Min-Kyung
Lee Song-Eun
Lee Young-Ik
Ryu Soo-Bang
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Abstract
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Purpose: Insulin like growth factor-1(IGF-1) is known to promote the proliferation and migration of penile cavernous smooth muscle cells in rat. The purpose of this study was to investigate whether IGF-1 could restore erectile function in the aging rat.
Materials and Methods: Male Sprague-Dawley rats were divided into two groups: young(4∼5 months; n=10) and old(24 months; n=30). The old group was further divided into vehicle only(phosphate buffered saline plus 0.1% bovine serum albumin; n=10) and IGF-1 treatment(100 μg; n=20) groups. Half of the IGF-1 dose(50 μg) was injected on the first day, and half was injected on the third day. After 2 and 4 weeks of treatment, erectile function was evaluated by hemodynamic study, and corpus cavernosal histology was examined by histomorphometric analysis.
Results: The ratio of peak intracavernosal pressure to systemic arterial blood pressure was significantly lower in the vehicle-only old rats(63.1⁑8.5%) compared to young rats(74.6⁑3.2%)(p=0.016). However, after 4 weeks of treatment, the ratio was significantly increased in the IGF-1 treatment group(77.2⁑7.0%) compared to the vehicle-only group(p＜0.05). The percentage of smooth muscle was significantly lower in the vehicle-only old rats(12.8⁑2.2%) compared to young rats(17.8⁑3.7%)(p=0.047), whereas, it was significantly increased in the IGF-1 treatment group (19.4⁑3.3%) compared to the vehicle-only group(p=0.014).
Conclusions: Intracavernosal injection of IGF-1 in the old rats resulted in increased intracavernosal pressure and higher percentage of cavernosal smooth muscle. These results suggest that intracavernosal injection of IGF-1 appears to restore smooth muscle integrity and improve erectile function in aged rats.
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KEYWORD
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Insulin-like growth factor 1, Penile erection, Injection
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